Richie and Jonny Gray will start for Scotland together for the first time against Argentina at Murrayfield on Saturday.
Mark Bennett, one of ten Glasgow Warriors players in the starting XV, will make his debut from outside centre.
The Gray brothers will support an experienced front-row trio of Alasdair Dickinson, Ross Ford and Euan Murray with Rob Harley, Blair Cowan and Adam Ashe in the back row.
In the backs, all but one player – captain Greig Laidlaw – have been picked from the Warriors’ with Finn Russell the half-back partner at stand-off, and Alex Dunbar starting alongside Bennett in midfield.
The back three of Stuart Hogg, Sean Maitland and Tommy Seymour in the wide channels complete the side.
“We’ve selected a group we believe can do the job against Argentina,” said head coach Vern Cotter.
“There is a genuine desire for this squad and those selected for the Test to play well for the jersey.”
“We have several performance-related themes, and have looked for people who have the ability to control games, take initiative, can pick up the ball and run with it, who like physical confrontation and can keep the ball alive.
“These are things that we have prioritised in our selection and we’re now all looking forward to getting out there and putting in a good performance in front of the Scottish people on Saturday.
“I really appreciate what Mark has done because he has been very patient and has been developing his performances week in, week out for Glasgow Warriors.
“Patience and working hard is what you want from your players.
“You can see his determination in the way he breaks the line and scores tries. I’m really pleased he’s developed that over the last couple of years and will now make his debut for his country, which is a very special achievement.
“When the players run out they’ll do it with a lot of pride and a lot of respect.
“There will be a common cause to have the confidence to attack and take the initiative against Argentina, which is arguably the most improved country in the world.
“We’ll try and put a cohesive effort out there technically and tactically, but I can assure you the players are, emotionally, very attached and are working extra hard to put in a good performance.
“So let’s be strong, let’s be passionate as we always are; play for the people that come to the stadium and the Scots in this country and around the world.”
Scotland: Stuart Hogg (Glasgow Warriors), Sean Maitland (Glasgow Warriors), Mark Bennett (Glasgow Warriors), Alex Dunbar (Glasgow Warriors), Tommy Seymour (Glasgow Warriors), Finn Russell (Glasgow Warriors), Greig Laidlaw CAPTAIN (Gloucester), Alasdair Dickinson (Edinburgh Rugby), Ross Ford (Edinburgh Rugby), Euan Murray (Glasgow Warriors), Richie Gray (Castres), Jonny Gray (Glasgow Warriors), Rob Harley (Glasgow Warriors), Blair Cowan (London Irish), Adam Ashe (Glasgow Warriors),
Replacements : Scott Lawson (Gloucester), Gordon Reid (Glasgow Warriors), Geoff Cross (London Irish), Tim Swinson (Glasgow Warriors), Alasdair Strokosch (Perpignan), Henry Pyrgos (Glasgow Warriors), Duncan Weir (Glasgow Warriors), Sean Lamont (Glasgow Warriors),
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