Justin Tipuric will miss Wales’ tour of New Zealand in June due to concussion.
The Ospreys flanker, 26, has been advised to take a three-month rest after a bang to the head playing for Wales against Italy on 19 March.
Wales play three Tests against the All Blacks on 11, 18 and 25 June as well as a midweek match against Waikato Chiefs.
International prop Paul James is also out for the season following eye surgery, while the Ospreys confirmed centre JJ Englebrecht and prop Ma’afu Fia will also not play again this term.
“Justin is recovering well,” said medic Chris Towers. “But in the light of his symptoms the advice is it is in his best interests to take time returning.
“A prolonged three-month period of recovery rules him out of the rest of the season for the Ospreys and the Wales tour to New Zealand.
“The focus for Justin will be on getting healthy and fit, ready for pre-season.”
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