La Rochelle captain Gregory Alldritt will lead France in the absence of Antoine Dupont, who will miss the Six Nations to join France's Sevens programme as he targets the Paris Olympics.
No.8 Alldritt has been chosen ahead of former skipper Charles Ollivon.
Dupont's replacement at No.9 will be either Maxime Lucu (Bordeaux) or the uncapped Nolann Le Garrec (Racing 92).
Fabien Galthie has named five other uncapped players – centre Nicolas Depoortere, flyhalf Antoine Gibert, flanker Esteban Abadie, plus locks Matthias Halagahu and Emmanuel Meafou.
FRANCE SQUAD
Forwards: Cyril Baille, Reda Wardi, Sebastien Taofifenua, Dorian Aldegheri, Uini Atonio, Thomas Laclayat, Julien Marchand, Peato Mauvaka, Gaetan Barlot, Emmanuel Meafou, Romain Taofifenua, Cameron Woki, Paul Gabrillagues, Matthias Halagahu, Gregory Alldritt, Francois Cros, Anthony Jelonch, Charles Ollivon, Esteban Abadie, Paul Boudehent
Backs: Nolann Le Garrec, Maxime Lucu, Antoine Gibert, Matthieu Jalibert, Jonathan Danty, Nicolas Depoortere, Gael Fickou, Yoram Moefana, Emilien Gailleton, Louis Bielle-Biarrey, Damian Penaud, Matthis Lebel, Melvyn Jaminet, Thomas Ramos
