Jack Clifford, Ollie Devoto and Paul Hill are in line to make their Test debut after being named in England match day squad to take on Scotland in the Six Nations opener on Saturday.
The trio are part of a 25-man squad named by new head coach Eddie Jones as Maro Itoje and Elliot Daly will also travel to Edinburgh as covers.
With Courtney Lawes struggling with a hamstring injury, the uncapped Itoje could still be named in the match-day squad while Wasps centre Daly, who is also uncapped, will provide cover for the back line.
Kieran Brookes (Northampton), Luke Cowan-Dickie (Exeter), Matt Kvesic (Gloucester), Matt Mullan (Wasps), Sam Hill (Exeter), Semesa Rokoduguni (Bath) and Marland Yarde (Harlequins) have all been released to their club and will be available to play in the Premiership.
England squad to take on Scotland
Backs: Mike Brown (Harlequins), Danny Care (Harlequins), Ollie Devoto (Bath), Owen Farrell (Saracens), George Ford (Bath), Alex Goode (Saracens), Jonathan Joseph (Bath), Jack Nowell (Exeter), Anthony Watson (Bath), Ben Youngs (Leicester).
Forwards: Dan Cole (Leicester), Jack Clifford (Harlequins), Jamie George (Saracens), Dylan Hartley (Northampton), James Haskell (Wasps), Paul Hill (Northampton), George Kruis (Saracens), Joe Launchbury (Wasps), Courtney Lawes (Northampton), Joe Marler (Harlequins), Chris Robshaw (Harlequins), Billy Vunipola (Saracens), Mako Vunipola (Saracens).
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