JOSH van der Flier starts in Leinster's back row after being released from the Ireland squad.
Jimmy O'Brien returns at full-back for the holders and Conference A leaders following a hamstring injury.
Scrum-half Luke McGrath captains the side, which also includes Dave Kearney and emerging fly-half Harry Byrne.
Ireland U20s forward Alex Soroka could make his Leinster debut after being named on the bench.
The 6ft 5in youngster, who turned 20 last week, can play at either lock or in the back row.
Leinster's starting pack includes Ireland internationals Sean Cronin, Michael Bent and Devin Toner.
Lock Toner will make his 258th appearance for the province as he moves ever closer to Gordon D'Arcy's all-time Leinster record caps total of 261.
Glasgow welcome back nine players from the Scotland camp in the wake of the postponed Six Nations fixture away to France, including front rowers Oli Kebble and Grant Stewart, and lock Richie Gray.
Full-back Ollie Smith will make their first Glasgow start, having agreed a professional contract with the Warriors this week. Huw Jones switches back to his old position of outside centre.
Former New Zealand U20s wing Cole Forbes makes his Glasgow debut, having signed this week.
Leinster go into the round of weekend fixtures leading Conference A by five points from Ulster.
Glasgow are 15 points adrift of third-placed Ospreys in the race for Champions Cup qualification.
LEINSTER: O'Brien; Kelleher, O'Loughlin, Frawley, Kearney; H Byrne, McGrath (c); Dooley, Cronin, Bent; Toner, Fardy; Murphy, Van der Flier, Penny
Replacements: Sheehan, G McGrath, Clarkson, Dunne, Soroka, R Osborne, Hawkshaw, J Osborne
GLASGOW: Smith; McLean, Jones, Johnson, Forbes; Hastings, Dobie; Kebble, Stewart, Pieretto; Gray, Nakarawa; Harley, Gordon, Wilson (c)
Replacements: Matthews, Seiuli, Rae, Brown, Ioane, Kennedy, Thompson, Ferguson